1. Raemali Malfe

Curado MP., et al. “Cancer Incidence in Five Continents.

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Raemali Malfe

This third edition of 'Cancer Biology' provides a clear and concise update of this well respected introductory texton the biological principles of the causes and treatment of cancer. The bookhas been updated to include areas of recent research to give a more student friendly approach. Several chapters have been revsied and expanded where appropriate, but it's overall comprehensive coverage of the subject has been maintained throughout.

Key features • concise introduction to the subject • comprehensive up-to-date coverage of key topics in cancer biology • chapters have been updated to include any new developments, where appropriate • illustrations have been amended toreflect current data • references have been moved to the end of each chapter • the glossary has been expanded 'Cancer Biology' is an essential text for students of cell biology, biochemistry, molecular biology, genetics and biomedical sciences. It will also be valuable to postgraduate students moving into cancer research. King is Honorary Professor in Cellular Oncology at Surrey University, UK.

He was formerly Chairman of the International Society for Hormones and Cancer, Head of the Hormone Biochemistry Department at the Imperial Cancer Research Fund Laboratories and a consultant to the World Health Organisation. Mike Robins was formally Senior Lecturer in Physiology at Kings College, London.

New to this edition • Extended chapter on the principles of cancer treatment, provides a useful insight into a fast-changing topic. • Captions added to figures and tables, to assist with easy reference and to help students visualise as they learn. • 4 colour plate section has been added to engage student interest. • Glossary fully updated, providing a useful resource for reference and revision.

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• Added references to useful websites, providing a resource which instuctors can use for assigning further reading and research. Table of contents Detailed contents Preface Preface to the second edition Preface to the first edition Acknowledgements Basic science, terminology and abbreviations 1. What is cancer? Introduction Carcinogenesis requires several cellular changes Lifestyle and family influences on cancer Changes continue to accumulate after cancer formation Cancers are most common in epithelial cells Cancer results from uncontrolled growth Cancer genes Invasion and metastasis Some cancers are curable Prevention, screening and treatment Further reading Websites 2. Natural history: the life of a cancer Introduction Clonal origins of cancer Experimental biology Box2.1: Special mice used in cancer research Clinical data Linking laboratory and clinic 3. Pathology: defining a neoplasm Introduction Box3.1: Classifying cancers Histopathology Cytology Immunohistochemistry Molecular techniques Further reading 4. Epidemiology: identifying causes for human cancers Introduction Descriptive epidemiology Box4.1: Epidemiological methods and terminology Analytical epidemiology Criteria required to establish causality Biomarkers Molecular epidemiology Factors that influence human carcinogenesis Cancer prevention Further reading 5.

Oncogenes, tumour suppressor genes and viruses Introduction Box5.1: Molecular terms relevant to genes and their regulation Oncogenes Tumour suppressor genes Oncogenes and tumour suppressors cooperate Further reading 6. Chemical and radiation carcinogenesis Introduction Chemical carcinogenesis Radiation carcinogenesis Consequences of DNA damage Predicting the type of carcinogen by mutational spectrum analysis Further reading 7. Mutations, DNA repair and genetic instability Introduction Mutations Genetic instability Types of DNA damage Clinical evidence that links DNA repair and carcinogenesis Repair mechanisms Coordination of DNA repair, proliferation and apoptosis Further reading 8.